Chlamydia pneumoniaeImpairs the Innate Immune Response in Infected Epithelial Cells by Targeting TRAF3

Immune Response in Infected Epithelial Impairs the Innate Chlamydia pneumoniae

The innate immune response of equine bronchial epithelial cells is altered by training

Respiratory diseases, including inflammatory airway disease (IAD), viral and bacterial infections, are common problems in exercising horses. The airway epithelium constitutes a major physical barrier against airborne infections and plays an essential role in the lung innate immune response mainly through toll-like receptor (TLR) activation. The aim of this study was to develop a model for the c...

Targeting Innate Immune Cells for Immunotherapy

Millennium Institute on Immunology and Immunotherapy, Santiago, Chile Programa de Inmunología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile Centro de Investigaciones Cooperativas en Biociencias (CIC bioGUNE), Bilbao, Spain Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia Departament...

Innate immune response in avian macrophages elicited by Chlamydia psittaci Aangeboren immuniteit van aviaire macrofagen geïnduceerd door Chlamydia psittaci

Chlamydia psittaci is a gram-negative, obligate, intracellular bacterium, which mainly infects birds and mammals. Not much is known about innate immunity initiated by C. psittaci. The focus of the present study is on chicken macrophage activation and expression of cytokine, chemokine, caspase-1, iNOS and TLR genes during the early phase and mid-cycle period of the developmental cycle of the hig...

Burkholderia pseudomallei Differentially Regulates Host Innate Immune Response Genes for Intracellular Survival in Lung Epithelial Cells

BACKGROUND Burkholderia pseudomallei, the causative agent of melioidosis poses a serious threat to humankind. B. pseudomallei secretes numerous virulence proteins that alter host cell functions to escape from intracellular immune sensors. However, the events underlying disease pathogenesis are poorly understood. METHODS We determined the ability of B. pseudomallei to invade and survive intrac...